methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate

Base Information

• Chemical Name: methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate
• CAS No.: 171858-41-6
• Molecular Formula: C₂₃H₃₅N₃O₅
• Molecular Weight: 433.548

Synonyms:methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate

Chemical Property of methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate

There total 4 articles about methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-Boc-L-valine (13734-41-3) → methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate (171858-41-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) <(benzotriazol-1-yloxy)tris(dimethylamino)phosphonium>hexafluorophosphonate, diisopropylethylamine, 2.) diisopropylethylamine / 1.) THF, 5 min, 2.) THF, 30 min

2: 1.) TFA, 2.) <(benzotriazol-1-yloxy)tris(dimethylamino)phosphonium>hexafluorophosphonate, diisopropylethylamine, 3.) diisopropylethylamine

3: 1.) TFA, 2.) diisopropylethylamine, DMAP / 1.) CH₂Cl₂, THF, 2.) THF, RT, 30 min

With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;

DOI:10.1021/ja00146a007

Reference yield:

N-tert-butoxycarbonyl-L-valyl-L-phenylalanine methyl ester (20902-47-0) → methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate (171858-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TFA, 2.) <(benzotriazol-1-yloxy)tris(dimethylamino)phosphonium>hexafluorophosphonate, diisopropylethylamine, 3.) diisopropylethylamine

2: 1.) TFA, 2.) diisopropylethylamine, DMAP / 1.) CH₂Cl₂, THF, 2.) THF, RT, 30 min

With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;

DOI:10.1021/ja00146a007

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate (171858-41-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) <(benzotriazol-1-yloxy)tris(dimethylamino)phosphonium>hexafluorophosphonate, diisopropylethylamine, 2.) diisopropylethylamine / 1.) THF, 5 min, 2.) THF, 30 min

2: 1.) TFA, 2.) <(benzotriazol-1-yloxy)tris(dimethylamino)phosphonium>hexafluorophosphonate, diisopropylethylamine, 3.) diisopropylethylamine

3: 1.) TFA, 2.) diisopropylethylamine, DMAP / 1.) CH₂Cl₂, THF, 2.) THF, RT, 30 min

With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;

DOI:10.1021/ja00146a007

upstream raw materials:

acetic anhydride

methyl (S)-2-<<(tert-butoxycarbonyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate

t-Boc-L-valine

N-tert-butoxycarbonyl-L-valyl-L-phenylalanine methyl ester

Downstream raw materials:

(S)-2-Acetylamino-4-methyl-pentanoic acid ((S)-1-{(S)-1-benzyl-3-[(8S,11S)-8-((S)-sec-butyl)-7,10-dioxo-2-oxa-6,9-diaza-bicyclo[11.2.2]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-11-ylamino]-2-oxo-propylcarbamoyl}-2-methyl-propyl)-amide

(S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-1-diazo-3-phenylbutan-2-one

(S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-1-bromo-3-phenylbutan-2-one

(S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 171858-41-6 methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send