4-[N',N''-bis(Boc)guanidino]mercaptophenol

Base Information

• Chemical Name: 4-[N',N''-bis(Boc)guanidino]mercaptophenol
• CAS No.: 545391-07-9
• Molecular Formula: C₁₇H₂₅N₃O₄S
• Molecular Weight: 367.469
• Mol file: 545391-07-9.mol

Synonyms:4-[N',N''-bis(Boc)guanidino]mercaptophenol

Chemical Property of 4-[N',N''-bis(Boc)guanidino]mercaptophenol

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-[N',N''-bis(Boc)guanidino]mercaptophenol

There total 1 articles about 4-[N',N''-bis(Boc)guanidino]mercaptophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine (207857-15-6) + 4-aminotiophenol (1193-02-8) → 4-[N',N''-bis(Boc)guanidino]mercaptophenol (545391-07-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ja0344213

Reference yield:

4-[N',N''-bis(Boc)guanidino]mercaptophenol (545391-07-9) → 2-benzyloxycarbonylamino-thiopropionic acid S-(4-guanidino-phenyl) ester (545391-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide; various solvent(s) / 37 °C / pH 8.0

In N,N-dimethyl-formamide;

DOI:10.1021/ja0344213

Reference yield:

4-[N',N''-bis(Boc)guanidino]mercaptophenol (545391-07-9) → (S)-2-(4-Guanidino-phenylsulfanylcarbonyl)-pyrrolidine-1-carboxylic acid benzyl ester (545391-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide; various solvent(s) / 37 °C / pH 8.0

In N,N-dimethyl-formamide;

DOI:10.1021/ja0344213

upstream raw materials:

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

4-aminotiophenol

Downstream raw materials:

2-benzyloxycarbonylamino-thiopropionic acid S-(4-guanidino-phenyl) ester

(S)-2-(4-Guanidino-phenylsulfanylcarbonyl)-pyrrolidine-1-carboxylic acid benzyl ester

2-benzyloxycarbonylamino-3-phenyl-thiopropionic acid S-(4-guanidino-phenyl) ester

(S)-4-Benzyloxycarbonylamino-4-(4-guanidino-phenylsulfanylcarbonyl)-butyric acid