(+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane

Base Information

Chemical Name:(+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane
CAS No.:321365-94-0
Molecular Formula:C₂₂H₂₆F₂N₂O
Molecular Weight:372.458
Hs Code.:

Synonyms:(+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane

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Chemical Property of (+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane

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Technology Process of (+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane

There total 5 articles about (+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321365-92-8
3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-9-methyl-3,9-diaza-bicyclo[4.2.1]nonane

: 321365-94-0
(+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane

Guidance literature:: 3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-9-methyl-3,9-diaza-bicyclo[4.2.1]nonane; With potassium carbonate; 2,2,2-Trichloroethyl chloroformate; In toluene; Heating;

With acetic acid; zinc; at 20 ℃; Further stages.;
DOI:10.1021/jm000300r

Reference yield:

: 50366-31-9
2-[bis(4-fluorophenyl)methoxy]ethyl chloride

: 321365-94-0
(+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / NaI / acetone / Heating

2.1: K₂CO₃ / tetrahydrofuran / Heating

3.1: 2,2,2-trichloroethyl chloroformate; K₂CO₃ / toluene / Heating

3.2: Zn; AcOH / 20 °C

With potassium carbonate; sodium iodide; 2,2,2-Trichloroethyl chloroformate; In tetrahydrofuran; acetone; toluene;
DOI:10.1021/jm000300r

Reference yield:

: 102547-84-2
9-methyl-3,9-diazabicyclo[4.2.1]nonane

: 321365-94-0
(+/-)-3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,9-diazabicyclo[4.2.1]nonane

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃ / tetrahydrofuran / Heating

2.1: 2,2,2-trichloroethyl chloroformate; K₂CO₃ / toluene / Heating

2.2: Zn; AcOH / 20 °C

With potassium carbonate; 2,2,2-Trichloroethyl chloroformate; In tetrahydrofuran; toluene;
DOI:10.1021/jm000300r