2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

Base Information

Chemical Name:2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline
CAS No.:1415354-07-2
Molecular Formula:C₂₀H₁₉ClN₂O₅
Molecular Weight:402.834
Hs Code.:

Synonyms:2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

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Chemical Property of 2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

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Technology Process of 2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

There total 3 articles about 2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

: 1190854-43-3
[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]boronic acid

: 1407104-66-8
2-chloro-8-methoxy-3-methyl-5-nitroquinoline

: 1415354-07-2
2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; for 2.5h; Reflux;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 132118-31-1
2-chloro-8-methoxy-3-methylquinoline

: 1415354-07-2
2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 3.5 h / -10 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 2.5 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; nitric acid; potassium carbonate; In 1,4-dioxane; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 7157-34-8
N-(2-methoxyphenyl)propionamide

: 1415354-07-2
2-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.25 h / 0 °C

1.2: 2.5 h / 70 °C

2.1: sulfuric acid; nitric acid / 3.5 h / -10 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 2.5 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; nitric acid; potassium carbonate; trichlorophosphate; In 1,4-dioxane; water; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028