Chemical Property of 7-[(1S,5R)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
Chemical Property:
- Vapor Pressure:2.59E-24mmHg at 25°C
- Melting Point:>250°C (dec.)
- Boiling Point:630.5°Cat760mmHg
- Flash Point:335.1°C
- PSA：164.20000
- Density:g/cm3
- LogP:3.24460
- Storage Temp.:Desiccate at RT
- Solubility.:DMSO: >10mg/mL
- Purity/Quality:
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97% *data from raw suppliers
Trovafloxacin mesylate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:C
- Statements:
63-34
- Safety Statements:
26-36-45
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 μg/ml) and DNA gyrase (IC50 = 7.13 μg/ml).
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Uses
Fluorinated quinolone antibacterial. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, enzymes essential in the repliction, transcription, and repair of bacterial DNA. Trovafloxacin mesylate has been used as a test compound in toxicity assay to assess its toxicity in 2D hepatocyte cultures. It has also been used to manipulate the mechanism of apoptotic cell disassembly during apoptosis.
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Therapeutic Function
Antibacterial
