2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

Base Information

Chemical Name:2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole
CAS No.:178174-03-3
Molecular Formula:C₁₂H₁₁ClF₃NO
Molecular Weight:277.674
Hs Code.:

Synonyms:2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

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Technology Process of 2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

There total 1 articles about 2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132630-83-2
2-(2,4,5-trifluoro-3-methylphenyl)-4,4-dimethyl-2-oxazoline

: 178174-03-3
2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: With 1,1,1,3,3,3-hexachloro-propan-2-one; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -60 deg C, 1 h, 2.) THF, a) -70 deg C, 1 h, b) -20 deg C, 2 h;
DOI:10.1248/cpb.44.1074

Reference yield: 75.0%

: 178174-03-3
2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 2-Chloro-3,4,6-trifluoro-5-methyl-benzoic acid 2-amino-2-methyl-propyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; at 70 ℃; for 3.5h;
DOI:10.1248/cpb.44.1074

Reference yield:

: 178174-03-3
2-(2-Chloro-3,4,6-trifluoro-5-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 2-(2-Chloro-3,4,6-trifluoro-5-methyl-benzoyl)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / 1N aq.HCl / 3.5 h / 70 °C

2: 100 percent / pyridine / 1 h / 50 °C

3: 95 percent / 1N aq.NaOH / 2 h / 100 °C

4: (COCl)2, DMF / CH₂Cl₂ / 2 h / Ambient temperature

5: 1.) EtOH, Mg, CCl₄ / 1.) toluene, 2.) toluene, RT, 2 h

With pyridine; hydrogenchloride; tetrachloromethane; sodium hydroxide; oxalyl dichloride; ethanol; magnesium; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1248/cpb.44.1074