11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester

Base Information

• Chemical Name: 11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester
• CAS No.: 116171-88-1
• Molecular Formula: C₂₆H₃₂N₂O₃
• Molecular Weight: 420.552

Synonyms:11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester

Chemical Property of 11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester

There total 8 articles about 11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester (107688-28-8,116260-69-6,116260-75-4) → 7-hydroxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester (107688-29-9,116260-66-3) + 11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester (116171-88-1)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; at 40 - 50 ℃; for 21h;

DOI:10.1016/S0040-4020(01)86863-0

Reference yield:

2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol (107688-23-3) → 11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester (116171-88-1)

Guidance literature:

Multi-step reaction with 6 steps

1: anhydrous sodium carbonate / tetrahydrofuran / 16 h / 50 °C

2: 98 percent / pyridine / 1 h / 40 °C

3: 98 percent / tetra-n-butyl ammonium bromide, sodium iodide / toluene / 2 h / Heating

4: 90 percent / sodium hydroxide, 30percent hydrogen peroxide / ethanol / 3 h / Ambient temperature

5: 77 percent / Amberlyst 15 / 120 h / 60 °C

6: acetic acid,H₂ / 10percent Pd/C / tetrahydrofuran / 21 h / 40 - 50 °C

With pyridine; sodium hydroxide; Amberlyst 15; tetrabutylammomium bromide; hydrogen; dihydrogen peroxide; sodium carbonate; acetic acid; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene;

DOI:10.1016/S0040-4020(01)86863-0

Reference yield:

3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaurenitril (107688-26-6,116260-70-9,116260-74-3) → 11-Benzyloxymethyl-5,6,7,8,9,10,11,12,13,14-decahydro-7,14-diaza-cycloundeca[a]indene-13-carboxylic acid methyl ester (116171-88-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / sodium hydroxide, 30percent hydrogen peroxide / ethanol / 3 h / Ambient temperature

2: 77 percent / Amberlyst 15 / 120 h / 60 °C

3: acetic acid,H₂ / 10percent Pd/C / tetrahydrofuran / 21 h / 40 - 50 °C

With sodium hydroxide; Amberlyst 15; hydrogen; dihydrogen peroxide; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/S0040-4020(01)86863-0

upstream raw materials:

3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaurenitril

3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-7-carbonsaureamid

2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol

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