2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone

Base Information

• Chemical Name: 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone
• CAS No.: 75347-53-4
• Molecular Formula: C₁₂H₁₀Cl₂O₃
• Molecular Weight: 273.116
• Mol file: 75347-53-4.mol

Synonyms:2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone

Chemical Property of 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone

There total 1 articles about 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tetrahydropyranyloxy)-4-pentyn (62992-46-5) + 2,5-dichloro-3,6-dimethoxy-1,4-benzoquinone (7210-71-1) + methyllithium (917-54-4) → 2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone (75347-53-4)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jo01313a009

Reference yield: 81.0%

2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone (75347-53-4) → 2,5-dichloro-3-(5-hydroxy-1-pentenyl)-6-methylhydroquinone (75365-46-7)

Guidance literature:

With hydrogen; Pd-BaSO₄; In pyridine; ethyl acetate; for 2h; Ambient temperature;

DOI:10.1021/jo01313a009

Reference yield:

2,5-dichloro-3-(5-hydroxy-1-pentynyl)-6-methyl-1,4-benzoquinone (75347-53-4) → 2,5-dichloro-3-(5-hydroxy-1-pentenyl)-6-methyl-1,4-benzoquinone (75347-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / H₂ / 5percent Pd/BaSO₄ / ethyl acetate; pyridine / 2 h / Ambient temperature

2: 67 percent / aq. ferric chloride / CHCl₃; methanol / 2 h / Ambient temperature

With hydrogen; iron(III) chloride; Pd-BaSO₄; In pyridine; methanol; chloroform; ethyl acetate;

DOI:10.1021/jo01313a009

upstream raw materials:

1-(tetrahydropyranyloxy)-4-pentyn

2,5-dichloro-3,6-dimethoxy-1,4-benzoquinone

methyllithium

Downstream raw materials:

2,5-dichloro-3-(5-hydroxy-1-pentenyl)-6-methylhydroquinone

2,5-dichloro-3-(5-hydroxy-1-pentenyl)-6-methyl-1,4-benzoquinone

2-acido-5-chloro-3-(5-hydroxy-1-pentenyl)-6-methyl-1,4-benzoquinone

5-acido-2-chloro-3-(5-hydroxy-1-pentenyl)-6-methyl-1,4-benzoquinone