1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

Base Information

Chemical Name:1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether
CAS No.:1421640-75-6
Molecular Formula:C₄₆H₈₈O₃Si₃
Molecular Weight:773.459
Hs Code.:

Synonyms:1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

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Chemical Property of 1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

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Technology Process of 1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

There total 4 articles about 1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1421640-74-5
1α,3β-bis[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne

: 1421640-75-6
1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

Guidance literature:: With quinoline; hydrogen; In hexane; at 20 ℃;
DOI:10.1021/jo302513e

Reference yield:

: 1421640-73-4
1α,3β-bis[(tert-butyldimethylsilyl)oxy]-9α-methyl-25-[(triethylsilyl)oxy]-9,10-secocholest-5(10)-en-6-yn-8β-ol

: 1421640-75-6
1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: Burgess Reagent / toluene / 0.5 h / 50 °C

2: quinoline; hydrogen / hexane / 20 °C

With quinoline; Burgess Reagent; hydrogen; In hexane; toluene;
DOI:10.1021/jo302513e

Reference yield:

: 144848-24-8
25-[(triethylsilyl)oxy]de-A,B-cholestan-8-one

: 1421640-75-6
1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; n-heptane; ethylbenzene / 1 h / -78 - -30 °C / Inert atmosphere

1.2: 4 h / -78 - -30 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: -78 - 20 °C / Inert atmosphere

3.1: Burgess Reagent / toluene / 0.5 h / 50 °C

4.1: quinoline; hydrogen / hexane / 20 °C

With quinoline; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; Burgess Reagent; hydrogen; lithium diisopropyl amide; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; toluene;
DOI:10.1021/jo302513e