ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate

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Chemical Name:ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate
CAS No.:922507-11-7
Molecular Formula:C₂₁H₂₁NO₄
Molecular Weight:351.402
Hs Code.:

Synonyms:ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate

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Chemical Property of ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate

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Technology Process of ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate

There total 8 articles about ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 922506-94-3
ethyl 1-allyl-4-(benzyloxy)-7-iodo-1H-indole-2-carboxylate

: 922507-11-7
ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate

: 8-benzyloxy-5-hydroxymethyl-4,5-dihydro-pyrrolo[3,2,1-hi]indole-2-carboxylic acid ethyl ester

Guidance literature:: ethyl 1-allyl-4-(benzyloxy)-7-iodo-1H-indole-2-carboxylate; With 2,2,6,6-tetramethyl-piperidine-N-oxyl; tri-n-butyl-tin hydride; In benzene; for 2.25h; Heating;

With acetic acid; zinc; In tetrahydrofuran; water; at 70 ℃; for 1.5h;
DOI:10.3390/10121446

Reference yield: 35.0%

: 922507-01-5
ethyl 4-(benzyloxy)-7-bromo-1-prop-2-ynyl-1H-indole-2-carboxylate

: 8-benzyloxy-5-methylene-4,5-dihydro-pyrrolo[3,2,1-hi]indole-2-carboxylic acid ethyl ester

: 922507-11-7
ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 2.5h; Heating;
DOI:10.3390/10121446

Reference yield:

: 922506-90-9
ethyl 4-(benzyloxy)-7-iodo-1H-indole-2-carboxylate

: 922507-11-7
ethyl 9-(benzyloxy)-5-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / potassium carbonate; sodium iodide / dimethylformamide / 24 h / 50 °C

2: 50 percent / AIBN; Bu₃SnH / benzene / 2.5 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; benzene;
DOI:10.3390/10121446