4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

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Chemical Name:4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one
CAS No.:934631-72-8
Molecular Formula:C₄₀H₅₅NO₇Si
Molecular Weight:689.965
Hs Code.:

4-benzyl-3-{3-[6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

Synonyms:4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

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Chemical Property of 4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

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Technology Process of 4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

There total 5 articles about 4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 934631-71-7
[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetaldehyde

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 934631-72-8
4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

Guidance literature:: (3R)-3-propionyl-4-benzyloxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at -78 - 0 ℃;

[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetaldehyde; In dichloromethane; at -78 - 0 ℃; for 1.5h;
DOI:10.1021/ol063143k

Reference yield:

: 934631-68-2
tert-butyl-(4-ethynyl-5,5-dimethyl-3,7-dioxa-bicyclo[4.1.0]hept-2-ylmethoxy)-diphenyl-silane

: 934631-72-8
4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / DIBAL-H / diethyl ether; hexane / 0 °C

2.1: 97 percent / DIEA / dimethylformamide / 0 - 20 °C

3.1: 76 percent / BH₃*SMe₂; 2-methyl-2-butene / tetrahydrofuran / 0 - 20 °C

4.1: Bu₂BOTf; triethylamine / CH₂Cl₂ / -78 - 0 °C

4.2: 93 percent / CH₂Cl₂ / 1.5 h / -78 - 0 °C

With 2-methyl-but-2-ene; dimethylsulfide borane complex; di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 4.2: aldol addition;
DOI:10.1021/ol063143k

Reference yield:

: 934631-69-3
6-(tert-butyl-diphenyl-silanyloxymethyl)-2-ethynyl-3,3-dimethyl-tetrahydro-pyran-4-ol

: 934631-72-8
4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / DIEA / dimethylformamide / 0 - 20 °C

2.1: 76 percent / BH₃*SMe₂; 2-methyl-2-butene / tetrahydrofuran / 0 - 20 °C

3.1: Bu₂BOTf; triethylamine / CH₂Cl₂ / -78 - 0 °C

3.2: 93 percent / CH₂Cl₂ / 1.5 h / -78 - 0 °C

With 2-methyl-but-2-ene; dimethylsulfide borane complex; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.2: aldol addition;
DOI:10.1021/ol063143k