trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester

Base Information

• Chemical Name: trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester
• CAS No.: 910052-74-3
• Molecular Formula: C₁₆H₁₅F₃N₂O₃S
• Molecular Weight: 372.368
• Mol file: 910052-74-3.mol

Synonyms:trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester

Chemical Property of trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester

There total 3 articles about trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

trifluoro-methanesulfonic acid 6-trifluoromethanesulfonyloxy-3-(2-trifluoromethanesulfonyloxy-ethyl)-pyridin-2-yl ester (910052-68-5) + rac-methylbenzylamine (618-36-0) → trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester (910052-74-3)

Guidance literature:

In dichloromethane; at 90 ℃; for 2h;

DOI:10.1021/ol061379i

Reference yield:

5-aza-spiro[2.5]oct-7-ene-4,6-dione (910052-67-4) → trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester (910052-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / CH₂Cl₂ / 0 - 20 °C

2: 84 percent / CH₂Cl₂ / 2 h / 90 °C

In dichloromethane;

DOI:10.1021/ol061379i

Reference yield:

(E)-3-(1-Carbamoyl-cyclopropyl)-acrylic acid methyl ester → trifluoro-methanesulfonic acid 1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl ester (910052-74-3)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuOK / tetrahydrofuran / 0.33 h / 70 °C

2: 30 percent / CH₂Cl₂ / 0 - 20 °C

3: 84 percent / CH₂Cl₂ / 2 h / 90 °C

With potassium tert-butylate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol061379i

upstream raw materials:

trifluoro-methanesulfonic acid 6-trifluoromethanesulfonyloxy-3-(2-trifluoromethanesulfonyloxy-ethyl)-pyridin-2-yl ester

rac-methylbenzylamine

5-aza-spiro[2.5]oct-7-ene-4,6-dione