[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester
• CAS No.: 114779-46-3
• Molecular Formula: C₃₅H₃₃N₃O₃
• Molecular Weight: 543.665

Synonyms:[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester

Chemical Property of [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester

Chemical Property:

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Technology Process of [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester

There total 4 articles about [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

→ [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester (114779-46-3)

Guidance literature:

Reference yield:

DL-α-methyltryptophan (153-91-3,13510-08-2) → [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester (114779-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / DIEA / H₂O; acetonitrile / 4.5 h / Ambient temperature

2: 1.) BOP, DIEA / 1.) DMF, RT, 45 min, 2.) DMF, RT, 7 d

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In water; acetonitrile;

DOI:10.1021/jm00072a005

Reference yield:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester (114779-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / DIEA / H₂O; acetonitrile / 4.5 h / Ambient temperature

2: 1.) BOP, DIEA / 1.) DMF, RT, 45 min, 2.) DMF, RT, 7 d

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In water; acetonitrile;

DOI:10.1021/jm00072a005

upstream raw materials:

N-(Fmoc)-DL-α-methyltryptophal

phenethylamine

DL-α-methyltryptophan

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

N-methyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide

N-ethyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide

N-isopropyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide

N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide

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