4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole

Base Information

Chemical Name:4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole
CAS No.:1027301-79-6
Molecular Formula:C₃₅H₃₁NO₄
Molecular Weight:529.635
Hs Code.:

Synonyms:4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole

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Chemical Property of 4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole

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Technology Process of 4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole

There total 5 articles about 4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60032-63-5
4-hydroxy-3-iodo-benzaldehyde

: 1027301-79-6
4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

2: 1.) LDA / 1.) THF, hexane, -10 deg C, 1 h, 2.) THF, hexane, from -10 deg C to RT, 2 h

3: p-TsOH*H₂O / Heating

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; toluene-4-sulfonic acid; lithium diisopropyl amide;
DOI:10.1021/jm960230h

Reference yield:

: 6813-61-2
2-(benzoylamino)-4-pentynoic acid

: 1027301-79-6
4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) H₂O / 1.) 90 deg c, 1 h, 2.) from 85 to 90 deg C, 20 min

2: trifluoroacetic acid anhydride / trifluoroacetic acid / 6 h / 35 - 40 °C

3: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

4: 1.) LDA / 1.) THF, hexane, -10 deg C, 1 h, 2.) THF, hexane, from -10 deg C to RT, 2 h

5: p-TsOH*H₂O / Heating

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; water; toluene-4-sulfonic acid; trifluoroacetic anhydride; lithium diisopropyl amide; In trifluoroacetic acid;
DOI:10.1021/jm960230h

Reference yield:

: 140130-09-2
4-benzoylamino-1-hexyn-5-one

: 1027301-79-6
4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid anhydride / trifluoroacetic acid / 6 h / 35 - 40 °C

2: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

3: 1.) LDA / 1.) THF, hexane, -10 deg C, 1 h, 2.) THF, hexane, from -10 deg C to RT, 2 h

4: p-TsOH*H₂O / Heating

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; toluene-4-sulfonic acid; trifluoroacetic anhydride; lithium diisopropyl amide; In trifluoroacetic acid;
DOI:10.1021/jm960230h