(1S,2S,5R)-(+)-dineomenthyl sulfide

Base Information

• Chemical Name: (1S,2S,5R)-(+)-dineomenthyl sulfide
• CAS No.: 1610675-38-1
• Molecular Formula: C₂₀H₃₈S
• Molecular Weight: 310.588
• Mol file: 1610675-38-1.mol

Synonyms:(1S,2S,5R)-(+)-dineomenthyl sulfide

Chemical Property of (1S,2S,5R)-(+)-dineomenthyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,5R)-(+)-dineomenthyl sulfide

There total 3 articles about (1S,2S,5R)-(+)-dineomenthyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

(1S,2S,5R)-(+)-neomenthyl thiol (53273-24-8,196622-67-0,223653-15-4,173006-99-0) + menthyl tosylate (2230-82-2) → (1S,2S,5R)-(+)-dineomenthyl sulfide (1610675-38-1)

Guidance literature:

(1S,2S,5R)-(+)-neomenthyl thiol; With sodium hydride; In mineral oil; Petroleum ether; at 20 ℃; for 0.5h; Inert atmosphere;

menthyl tosylate; In mineral oil; Petroleum ether; for 24h; Reflux;

DOI:10.1080/10426507.2013.819867

Reference yield:

menthyl tosylate (2230-82-2) → (1S,2S,5R)-(+)-dineomenthyl sulfide (1610675-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thiourea / isopropyl alcohol / 15 h / 100 °C

1.2: 2 h / 100 °C

2.1: sodium hydride / Petroleum ether; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 24 h / Reflux

With sodium hydride; thiourea; In isopropyl alcohol; mineral oil; Petroleum ether;

DOI:10.1080/10426507.2013.819867

Reference yield:

Neomenthyl thioacetate (103532-45-2) → (1S,2S,5R)-(+)-dineomenthyl sulfide (1610675-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / Reflux; Inert atmosphere

2.1: sodium hydride / Petroleum ether; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 24 h / Reflux

With lithium aluminium tetrahydride; sodium hydride; In diethyl ether; mineral oil; Petroleum ether;

DOI:10.1080/10426507.2013.819867

upstream raw materials:

menthyl tosylate

(1S,2S,5R)-(+)-neomenthyl thiol

Neomenthyl thioacetate