4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

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Chemical Name:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate
CAS No.:1362688-83-2
Molecular Formula:C₃₁H₄₇N₆O₈P
Molecular Weight:662.723
Hs Code.:

Synonyms:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

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Chemical Property of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

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Technology Process of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

There total 4 articles about 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₅₅N₆O₁₀P

: 1362688-83-2
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

Guidance literature:: C₃₆H₅₅N₆O₁₀P; With phosphoric acid; In chloroform; water; at 20 ℃; for 4.5h;

With water; sodium hydroxide; at 0 - 5 ℃; pH=7;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 15687-27-1,58560-75-1
ibuprofen

: 1362688-83-2
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1362688-83-2
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013