1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione
• CAS No.: 110164-36-8
• Molecular Formula: C₂₃H₂₈N₄O₅S
• Molecular Weight: 472.565

Synonyms:1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

Chemical Property of 1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

Chemical Property:

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Technology Process of 1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

There total 8 articles about 1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-06-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-36-8)

Guidance literature:

In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1021/jo00001a046

Reference yield: 47.0%

Methyl 3-bromopropionate (3395-91-3) + 3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-1H-thieno[3,4-d]pyrimidine-2,4-dione; hydrochloride (110164-48-2) → 1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-36-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1021/jm00117a019

Reference yield: 47.0%

→ 1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-36-8)

Guidance literature:

upstream raw materials:

Methyl 3-bromopropionate

3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-1H-thieno[3,4-d]pyrimidine-2,4-dione; hydrochloride

3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

acrylic acid methyl ester

Downstream raw materials:

3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid

3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

9-amino-3,4,5,7,8,9-hexahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

3,4,5,7,8,9-hexahydro-9-hydroxy-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

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