1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Name:1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
CAS No.:1425937-23-0
Molecular Formula:C₂₄H₂₁FN₄O₃
Molecular Weight:432.454
Hs Code.:

Synonyms:1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Property of 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Technology Process of 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

There total 7 articles about 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425937-22-9
5-(benzyloxy)-1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

: 1425937-23-0
1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: With hydrogen bromide; acetic acid; at 50 ℃; for 12h;

Reference yield:

: 75329-65-6
1-(benzyloxy)-2,4-pentanedione

: 1425937-23-0
1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / Cooling with ice

1.2: 3 h / 0 - 35 °C

2.1: N,N-dimethyl-formamide / 5 h / 80 °C

2.2: 0 - 35 °C

3.1: hydrogen bromide; acetic acid / 12 h / 50 °C

With hydrogenchloride; hydrogen bromide; acetic acid; sodium nitrite; In water; N,N-dimethyl-formamide;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1425937-23-0
1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium diacetate; caesium carbonate; XPhos / 1,2-dimethoxyethane; water / 12 h / 90 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 10 - 35 °C

3.1: hydrogenchloride; sodium nitrite / water / Cooling with ice

3.2: 3 h / 0 - 35 °C

4.1: N,N-dimethyl-formamide / 5 h / 80 °C

4.2: 0 - 35 °C

5.1: hydrogen bromide; acetic acid / 12 h / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen bromide; hydrogen; palladium diacetate; caesium carbonate; acetic acid; sodium nitrite; XPhos; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;