ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate

Base Information

• Chemical Name: ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate
• CAS No.: 1338650-82-0
• Molecular Formula: C₂₄H₂₀N₆O₄
• Molecular Weight: 456.461

Synonyms:ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate

Chemical Property of ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate

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Technology Process of ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate

There total 2 articles about ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl 2-{2-[3-(hydroxymethyl)-1-phenyl-1H-pyrazol-3-yl]quinoxalin-2-yl}hydrazinyl-2-oxoacetate (1338650-79-5) + acetic anhydride (108-24-7) → ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate (1338650-82-0)

Guidance literature:

for 1h; Reflux;

DOI:10.1002/jhet.694

Reference yield:

2-hydrazino-3-<5-hydroxymethyl-1-phenylpyrazol-3-yl>quinoxaline (156635-75-5) → ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate (1338650-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 8 h / Reflux

2: 1 h / Reflux

In 1,4-dioxane;

DOI:10.1002/jhet.694

Reference yield: 90.0%

ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate (1338650-82-0) → 4-[5-(hydroxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbohydrazide (1338650-84-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 10h; Reflux;

DOI:10.1002/jhet.694

upstream raw materials:

ethyl 2-{2-[3-(hydroxymethyl)-1-phenyl-1H-pyrazol-3-yl]quinoxalin-2-yl}hydrazinyl-2-oxoacetate

acetic anhydride

2-hydrazino-3-<5-hydroxymethyl-1-phenylpyrazol-3-yl>quinoxaline

Downstream raw materials:

{3-[1-(1,2-diacetylhydrazinecarbonyl)-[1,2,4]triazolo[4,3-a]quioxalin-4-yl]-1-phenyl-1H-pyrazol-5-yl}methyl acetate

4-[5-(hydroxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbohydrazide

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