Technology Process of rel-(2R,6R,7S,8S)-7-butyl-8-hydroxy-2-<5-(2-nitro-4azidophenoxy)pentyl>-1-azaspiro<5.5>undecane
There total 8 articles about rel-(2R,6R,7S,8S)-7-butyl-8-hydroxy-2-<5-(2-nitro-4azidophenoxy)pentyl>-1-azaspiro<5.5>undecane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 33 percent / 32 h / 25 °C
2: 0.95 g / phosphorus pentasulfide / benzene / 4 h / Heating
3: 91 percent / sodium hydroxide / methanol / 3 h / 25 °C
4: 100 percent / CH2Cl2 / 18 h / Ambient temperature
5: 1.) magnesium, 2.) magnesium chloride / 1.) ether, 2.) dichloromethane, reflux, 24 h
6: 71 percent / aluminum hydride / toluene / 1.) -72 deg , 5 h, 2.) 25 deg C, 14 h
8: potassium tert-butoxide / tetrahydrofuran / 14 h / Ambient temperature
With
aluminium hydride; diphosphorus pentasulfide; sodium hydroxide; potassium tert-butylate; magnesium; magnesium chloride;
In
tetrahydrofuran; methanol; dichloromethane; toluene; benzene;
DOI:10.1021/ja00377a026
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / CH2Cl2 / 18 h / Ambient temperature
2: 1.) magnesium, 2.) magnesium chloride / 1.) ether, 2.) dichloromethane, reflux, 24 h
3: 71 percent / aluminum hydride / toluene / 1.) -72 deg , 5 h, 2.) 25 deg C, 14 h
5: potassium tert-butoxide / tetrahydrofuran / 14 h / Ambient temperature
With
aluminium hydride; potassium tert-butylate; magnesium; magnesium chloride;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja00377a026
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) magnesium, 2.) magnesium chloride / 1.) ether, 2.) dichloromethane, reflux, 24 h
2: 71 percent / aluminum hydride / toluene / 1.) -72 deg , 5 h, 2.) 25 deg C, 14 h
4: potassium tert-butoxide / tetrahydrofuran / 14 h / Ambient temperature
With
aluminium hydride; potassium tert-butylate; magnesium; magnesium chloride;
In
tetrahydrofuran; toluene;
DOI:10.1021/ja00377a026
