(3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine

Base Information

Chemical Name:(3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine
CAS No.:1310339-91-3
Molecular Formula:C₃₁H₃₇NO₅
Molecular Weight:503.638
Hs Code.:

Synonyms:(3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine

Chemical Property:

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Technology Process of (3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine

There total 3 articles about (3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: (2R/S,3S,4R,5R)-1-tert-butyloxycarbonyl-3,4-bis(benzyloxy)-5-(benzyloxymethyl)-2-(pyridin-2-ylthio)pyrrolidine

: 140-88-5,9003-32-1
ethyl acrylate

: 1310339-91-3
(3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine

: 1310339-94-6
(2R,3R,4R,5R)-1-tert-butyloxycarbonyl 3,4-bis(benzyloxy)-2-(benzyloxymethyl)-5-[(2-ethyloxycarbonyl)ethyl]pyrrolidine

Guidance literature:: With samarium diiodide; boron trifluoride diethyl etherate; tert-butyl alcohol; In tetrahydrofuran; at -60 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo200600n

Reference yield: 60.0%

: 1329714-94-4
C₃₁H₃₇NO₆

: 1310339-91-3
(3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine

Guidance literature:: With samarium diiodide; boron trifluoride diethyl etherate; ethyl acrylate; tert-butyl alcohol; In tetrahydrofuran; at -40 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/jo200600n

Reference yield:

: 944544-00-7
(3S,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxy-pyrrolidin-2-one

: 1310339-91-3
(3R,4R,5R)-5-benzyloxymethyl-1-(tert-butoxycarbonyl)-3,4-dibenzyloxypyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 1 h / -13 °C

2: samarium diiodide; boron trifluoride diethyl etherate; ethyl acrylate; tert-butyl alcohol / tetrahydrofuran / 0.17 h / -40 °C / Inert atmosphere

With sodium tetrahydroborate; samarium diiodide; boron trifluoride diethyl etherate; ethyl acrylate; tert-butyl alcohol; In tetrahydrofuran; methanol;
DOI:10.1021/jo200600n