tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate
CAS No.:1391001-30-1
Molecular Formula:C₂₂H₂₆ClN₇O₄
Molecular Weight:487.946
Hs Code.:

Synonyms:tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

There total 8 articles about tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1388816-82-7
tert-butyl 4-(4-(6-amino-5-carbamoyl-2-chloropyrimidin-4-ylamino)-3-methoxyphenyl)-piperazine-1-carboxylate

: 122-51-0
orthoformic acid triethyl ester

: 1391001-30-1
tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: at 140 ℃; for 12h;

Reference yield:

: 93416-51-4
2,4,6-trichloropyrimidine-5-carboxylic acid

: 1391001-30-1
tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2.25 h / 0 °C

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 48 h / 100 °C

3.1: 12 h / 140 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1391001-30-1
tert-butyl 4-(4-(2-chloro-5-oxo-5,6-dihydropyrimido[4,5-d]pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2: hydrogen / Raney nickel / methanol / 5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 48 h / 100 °C

4: 12 h / 140 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; Raney nickel; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;