3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide

Base Information

• Chemical Name: 3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide
• CAS No.: 1308400-96-5
• Molecular Formula: C₂₈H₂₃NO₂
• Molecular Weight: 405.496
• Mol file: 1308400-96-5.mol

Synonyms:3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide

Chemical Property of 3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide

There total 4 articles about 3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H10O3 (1308401-07-1) → 3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide (1308400-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 16.5 h / 0 - 20 °C / Inert atmosphere

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; triethylamine; In dichloromethane;

DOI:10.1002/anie.201100152

Reference yield:

2-methoxy-6-methyl-benzaldehyde (54884-55-8) → 3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide (1308400-96-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: sodium hydroxide / methanol; water / 17 h / 20 °C / Inert atmosphere

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h / 0 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 16.5 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water;

DOI:10.1002/anie.201100152

Reference yield:

C12H12O3 (1174514-48-7) → 3-(2-methoxy-6-methylphenyl)propynoic acid benzylnaphthalen-2-ylamide (1308400-96-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water / 17 h / 20 °C / Inert atmosphere

2: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: triethylamine / dichloromethane / 16.5 h / 0 - 20 °C / Inert atmosphere

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; triethylamine; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1002/anie.201100152

upstream raw materials:

C₁₂H₁₂O₃

C₁₁H₁₀O₃

2-(2,2-dibromoethenyl)-1-methoxy-3-methylbenzene

2-methoxy-6-methyl-benzaldehyde