Technology Process of (2S,3S,4S)-(1-benzyl-2-cyano-4-propyl-azetidin-3-yl)-acetic acid ethyl ester
There total 7 articles about (2S,3S,4S)-(1-benzyl-2-cyano-4-propyl-azetidin-3-yl)-acetic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 - -10 ℃;
for 2h;
DOI:10.1039/b509514j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium borohydride / ethanol / 2 h / 20 °C
2: 74 percent / K2CO3 / acetonitrile / 2.5 h / Heating
3: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.5 h / -78 °C
4: CH2Cl2 / -78 - 20 °C
5: 45 percent / LiHMDS / tetrahydrofuran / 2 h / -78 - -10 °C
With
sodium tetrahydroborate; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
3: Swern oxidation / 4: Wittig olefination;
DOI:10.1039/b509514j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 percent / K2CO3 / acetonitrile / 2.5 h / Heating
2: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.5 h / -78 °C
3: CH2Cl2 / -78 - 20 °C
4: 45 percent / LiHMDS / tetrahydrofuran / 2 h / -78 - -10 °C
With
oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; acetonitrile;
2: Swern oxidation / 3: Wittig olefination;
DOI:10.1039/b509514j
