3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

Base Information

Chemical Name:3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one
CAS No.:179024-54-5
Molecular Formula:C₁₈H₁₇N₃O
Molecular Weight:291.352
Hs Code.:

Synonyms:3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

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Chemical Property of 3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

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Technology Process of 3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

There total 6 articles about 3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 179024-51-2
3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

: 179024-54-5
3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

Guidance literature:: 3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one; With (R)-N-acetylphenylalanin; In ethyl acetate; Heating;

With sodium hydroxide; In water; ethyl acetate; at 0 ℃; Further stages.;
DOI:10.1021/jm000315p

Reference yield:

: 179024-53-4
9-methyl-1-phenyl-6,7-dihydro[1,4]diazepino[6,7,1-hi]indole-3,4-dione 3-oxime

: 179024-54-5
3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

Guidance literature:: 9-methyl-1-phenyl-6,7-dihydro[1,4]diazepino[6,7,1-hi]indole-3,4-dione 3-oxime; With hydrogen; Ru-carbon; In methanol; under 3000.24 Torr;

With (S)-2-acetylamino-3-phenylpropanoic acid;
DOI:10.1016/S0960-894X(99)00573-9

Reference yield:

: 179024-52-3
9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

: 179024-54-5
3-amino-9-methyl-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran; toluene / 30 h / -5 - 0 °C

1.2: 70 percent / isoamyl nitrite / tetrahydrofuran; toluene / 0.5 h / 0 °C

2.1: 68 percent / H₂ / 5percent Ru/C / methanol / 2 h / 80 °C / 6000.6 Torr

3.1: N-acetyl-D-phenylalanine / ethyl acetate / Heating

3.2: 91 percent / 1 N NaOH / ethyl acetate; H₂O / 0 °C

With (R)-N-acetylphenylalanin; potassium tert-butylate; hydrogen; 5percent Ru/C; In tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1021/jm000315p