(S)-ethyl 2-((R)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-4-oxopentanoate

Base Information

• Chemical Name: (S)-ethyl 2-((R)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-4-oxopentanoate
• CAS No.: 1088105-31-0
• Molecular Formula: C₂₆H₃₆O₄Si
• Molecular Weight: 440.655
• Mol file: 1088105-31-0.mol

Synonyms:(S)-ethyl 2-((R)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-4-oxopentanoate

Chemical Property of (S)-ethyl 2-((R)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-4-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-ethyl 2-((R)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-4-oxopentanoate

There total 2 articles about (S)-ethyl 2-((R)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

(E)-ethyl 4-oxo-2-pentenoate (6742-53-6,10150-93-3,200628-30-4) + propionaldehyde (123-38-6) + tert-butylchlorodiphenylsilane (58479-61-1) → (S)-ethyl 2-((R)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-4-oxopentanoate (1088105-31-0) + C26H36O4Si

Guidance literature:

(E)-ethyl 4-oxo-2-pentenoate; propionaldehyde; With (S)-4,5-dihydro-3H-dinaphtho[2,1-c:1′,2′-e]azepine; In toluene; for 51h;

With sodium tetrahydroborate; In ethanol; toluene; at -78 ℃;

tert-butylchlorodiphenylsilane; With 1H-imidazole; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1002/anie.201705546

Reference yield:

C12H22O5 + tert-butylchlorodiphenylsilane (58479-61-1) → (S)-ethyl 2-((R)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-4-oxopentanoate (1088105-31-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; optical yield given as %ee;

DOI:10.1021/ol802354u

upstream raw materials:

tert-butylchlorodiphenylsilane

(E)-ethyl 4-oxo-2-pentenoate

propionaldehyde