3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione

Base Information

• Chemical Name: 3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione
• CAS No.: 28421-57-0
• Molecular Formula: C₃₂H₃₉N₃O₅
• Molecular Weight: 545.679
• Mol file: 28421-57-0.mol

Synonyms:3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione

Chemical Property of 3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione

There total 8 articles about 3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) → 3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione (28421-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃ / 1 h / Ambient temperature

2: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -78 deg C, 2.5 h

With dimethylsulfide; ozone; In chloroform;

DOI:10.1016/0040-4039(92)80013-A

Reference yield:

ergosterol acetate (1108-03-8,2874-25-1,3957-39-9,57760-54-0,60018-28-2,78148-63-7,125225-12-9,2418-45-3) → 3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione (28421-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃ / 1 h / Ambient temperature

2: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -78 deg C, 2.5 h

With dimethylsulfide; ozone; In chloroform;

DOI:10.1016/0040-4039(92)80013-A

Reference yield:

3β-acetoxy-5α,8α-(4-phenyl-1,2,4-triazolidine-3,5-dione-1,2-diyl)ergosta-6,22-diene (28421-56-9) → 3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-23,24-dinor-cholane)-21,3',5'-trione (28421-57-0)

Guidance literature:

With dimethylsulfide; ozone; Multistep reaction; 1.) CH₂Cl₂, -78 deg C, 2.5 h;

DOI:10.1016/0040-4039(92)80013-A

upstream raw materials:

3β-acetoxy-5α,8α-(4-phenyl-1,2,4-triazolidine-3,5-dione-1,2-diyl)ergosta-6,22-diene

3-acetoxy-2'-phenyl-[1,2,4]triazolo[1',2':6,7](6,7-diaza-5,8-etheno-ergost-22-ene)-3',5'-dione

4-Phenylurazole

ergosterol acetate

Downstream raw materials:

3β-acetoxy-22,25-dihydroxy-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidino)cholesta-6-en-24-one

(22E)-3β-acetoxy-25-hydroxy-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidino)cholesta-6,22-dien-24-one

C₃₇H₄₉N₃O₅

C₄₅H₅₇N₃O₉S