11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide

Base Information

• Chemical Name: 11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide
• CAS No.: 616874-76-1
• Molecular Formula: C₃₉H₅₂BrF₂N₃O₂
• Molecular Weight: 712.762
• Mol file: 616874-76-1.mol

Synonyms:11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide

Chemical Property of 11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide

There total 1 articles about 11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

11-bromoundecanoic acid (2834-05-1) + 4-[3-(4-{2-[bis-(4-fluoro-phenyl)methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenylamine (616875-76-4) → 11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide (616874-76-1)

Guidance literature:

11-bromoundecanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.5h;

4-[3-(4-{2-[bis-(4-fluoro-phenyl)methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenylamine; In tetrahydrofuran; at 20 ℃; for 96h;

DOI:10.1016/S0040-4020(03)01179-7

Reference yield: 54.0%

11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide (616874-76-1) + potassium thioacetate (10387-40-3) → thioacetic acid S-[10-(4-{3-[(4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl)propyl]phenyl}carbamoyl)decyl] ester (616875-77-5)

Guidance literature:

In N,N-dimethyl-formamide; for 48h;

DOI:10.1016/S0040-4020(03)01179-7

Reference yield:

11-bromoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide (616874-76-1) → 11-mercaptoundecanoic acid (4-{3-[4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl]propyl}phenyl)amide

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / dimethylformamide / 48 h

2: 51 percent / NH₃ / methanol / 2 h / 20 °C

With ammonia; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(03)01179-7

upstream raw materials:

11-bromoundecanoic acid

4-[3-(4-{2-[bis-(4-fluoro-phenyl)methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenylamine

Downstream raw materials:

thioacetic acid S-[10-(4-{3-[(4-(2-(4,4'-fluorobenzhydryloxy)ethyl)piperazin-1-yl)propyl]phenyl}carbamoyl)decyl] ester