2,5-diamino-4-benzylamino-6-chloropyrimidine

Base Information

• Chemical Name: 2,5-diamino-4-benzylamino-6-chloropyrimidine
• CAS No.: 186416-92-2
• Molecular Formula: C₁₁H₁₂ClN₅
• Molecular Weight: 249.703
• Mol file: 186416-92-2.mol

Synonyms:2,5-diamino-4-benzylamino-6-chloropyrimidine

Chemical Property of 2,5-diamino-4-benzylamino-6-chloropyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-diamino-4-benzylamino-6-chloropyrimidine

There total 5 articles about 2,5-diamino-4-benzylamino-6-chloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,5-diamino-4,6-dichloropyrimidine (55583-59-0) + benzylamine (100-46-9) → 2,5-diamino-4-benzylamino-6-chloropyrimidine (186416-92-2)

Guidance literature:

With triethylamine; In butan-1-ol; for 48h; Heating;

DOI:10.1002/jhet.5570330609

Reference yield: 22.0%

2-amino-4-benzylamino-5-(p-chlorophenylazo)-6-chloropyrimidine (186416-91-1) → 2,5-diamino-4-benzylamino-6-chloropyrimidine (186416-92-2)

Guidance literature:

With acetic acid; zinc; In ethanol; for 4h; Heating;

DOI:10.1002/jhet.5570330609

Reference yield:

6-chloro-N4-benzyl-2,4-pyrimidinediamine (91066-67-0) → 2,5-diamino-4-benzylamino-6-chloropyrimidine (186416-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) conc. aq. HCl, NaNO₂, 2.) NaOAc, aq. AcOH / 1.) 0 deg C, 15 min, 2.) RT, 24 h

2: 22 percent / Zn, aq. AcOH / ethanol / 4 h / Heating

With hydrogenchloride; sodium acetate; acetic acid; zinc; sodium nitrite; In ethanol;

DOI:10.1002/jhet.5570330609

upstream raw materials:

2-amino-4-benzylamino-5-(p-chlorophenylazo)-6-chloropyrimidine

2,5-diamino-4,6-dichloropyrimidine

benzylamine

6-chloro-N⁴-benzyl-2,4-pyrimidinediamine

Downstream raw materials:

7-Allyl-2-amino-9-benzyl-6-chloro-7,9-dihydro-purin-8-one

9-benzyl-8-azaguanine

2-amino-9-benzyl-6-chloro-9H-purine

benzyl-(9-benzyl-2-iodo-9H-purin-6-yl)-amine

Refernces

• 1、 Sznaidman,Beauchamp. "Regioselective synthesis of 9-substituted-8-azaguanines (5-amino-3-substituted-3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7 -one)". . p. 1605 - 1610. Retrieved 2007/10/03.