H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2

Base Information

• Chemical Name: H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
• CAS No.: 137061-48-4
• Molecular Formula: C203H331N63O53S1
• Molecular Weight: 4534.26
• Mol file: 137061-48-4.mol

Synonyms:PeptidePACAP; PACAP; Pituitary adenylate cyclase-activating polypeptide

Chemical Property of H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

PACAP-38 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Biological functions: PACAP has pleiotropic functions in the central nervous system and peripheral tissues. PACAP acts as a neurotransmitter (neuromodulator), neuroprotectant, neurite outgrowth factor, and inducer of neural stem cell differentiation into astrocytes in nervous tissues. In peripheral tissues, PACAP acts as a bronchodilator, vasodilator, smooth muscle relaxant, adrenergic secretagogue in the adrenal gland, insulin secretagogue in the pancreas, inducer of spermatogenesis in testis, and immunosuppressor. PACAP also regulates the synthesis and secretion of hormones from the pituitary gland.
• Description: PACAP consists of 27 or 38 aa residues and belongs to the secretin/glucagon superfamily. PACAP has pleiotropic functions, acting as a neurotransmitter and neurotrophic factor in the central nervous system as well as a vasodilator, insulin secretagogue, smooth muscle relaxant, and immunosuppressor in peripheral tissues. PACAP was first isolated in 1989 from the extract of ovine hypothalamus on the basis of its ability to elevate cAMP levels in rat anterior pituitary cells.
• Uses: Pituitary adenylate cyclase activating polypeptide-38 has been used to test its effect in stimulating the formation of cyclic AMP hypothalamus and cerebral cortex slices of chicken and to treat glioblastoma cells (U87MG) in cell migration assay to test its anti-invasive effects.