Chemical Property of H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
Chemical Property:
- PSA：0.00000
- LogP:0.00000
- Storage Temp.:−20°C
- Purity/Quality:
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99%, *data from raw suppliers
PACAP-38 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
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Biological functions
PACAP has pleiotropic functions in the central nervous
system and peripheral tissues. PACAP acts as a neurotransmitter (neuromodulator), neuroprotectant, neurite
outgrowth factor, and inducer of neural stem cell differentiation into astrocytes in nervous tissues. In peripheral
tissues, PACAP acts as a bronchodilator, vasodilator,
smooth muscle relaxant, adrenergic secretagogue in the
adrenal gland, insulin secretagogue in the pancreas,
inducer of spermatogenesis in testis, and immunosuppressor. PACAP also regulates the synthesis and secretion of hormones from the pituitary gland.
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Description
PACAP consists of 27 or 38 aa residues and belongs to
the secretin/glucagon superfamily. PACAP has pleiotropic
functions, acting as a neurotransmitter and neurotrophic factor in the central nervous system as well as a vasodilator,
insulin secretagogue, smooth muscle relaxant, and immunosuppressor in peripheral tissues. PACAP was first isolated in 1989 from the extract of
ovine hypothalamus on the basis of its ability to elevate
cAMP levels in rat anterior pituitary cells.
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Uses
Pituitary adenylate cyclase activating polypeptide-38 has been used to test its effect in stimulating the formation of cyclic AMP hypothalamus and cerebral cortex slices of chicken and to treat glioblastoma cells (U87MG) in cell migration assay to test its anti-invasive effects.
