5-methyl-5,10-dideazafolic acid

Base Information

Chemical Name:5-methyl-5,10-dideazafolic acid
CAS No.:115758-41-3
Molecular Formula:C₂₂H₂₃N₅O₆
Molecular Weight:453.455
Hs Code.:

Synonyms:5-methyl-5,10-dideazafolic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-methyl-5,10-dideazafolic acid

Chemical Property:

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Technology Process of 5-methyl-5,10-dideazafolic acid

There total 8 articles about 5-methyl-5,10-dideazafolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 110202-60-3
5-methyl-5,10-dideazaaminopterin

: 115758-41-3
5-methyl-5,10-dideazafolic acid

Guidance literature:: With sodium hydroxide; for 5h; Heating;
DOI:10.1021/jm00119a018

Reference yield:

: 1253-46-9
4-methoxycarbonylbenzyltriphenylphosphonium bromide

: 115758-41-3
5-methyl-5,10-dideazafolic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 34 percent / NaOMe / dimethylformamide / 168 h / 20 - 25 °C

2: 51 percent / H₂ / Pd on C / dimethylformamide

3: 64 percent / NaOH / dimethylsulfoxide / 24 h / 20 - 25 °C

4: 1.) Et₃N, i-BuOCOCl / 1.) 20 deg C to 25 deg C, 30 min, 0 deg C to 5 deg C, 2 h, 2.) 23 deg C to 25 deg C, 2 days

5: 75 percent / NaOH / dimethylsulfoxide / 18 h / 23 - 25 °C

6: 85 percent / NaOH / 5 h / Heating

With sodium hydroxide; hydrogen; sodium methylate; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a018

Reference yield:

: 101810-74-6
2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carboxaldehyde

: 115758-41-3
5-methyl-5,10-dideazafolic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 34 percent / NaOMe / dimethylformamide / 168 h / 20 - 25 °C

2: 51 percent / H₂ / Pd on C / dimethylformamide

3: 64 percent / NaOH / dimethylsulfoxide / 24 h / 20 - 25 °C

4: 1.) Et₃N, i-BuOCOCl / 1.) 20 deg C to 25 deg C, 30 min, 0 deg C to 5 deg C, 2 h, 2.) 23 deg C to 25 deg C, 2 days

5: 75 percent / NaOH / dimethylsulfoxide / 18 h / 23 - 25 °C

6: 85 percent / NaOH / 5 h / Heating

With sodium hydroxide; hydrogen; sodium methylate; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a018