ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate

Base Information

• Chemical Name: ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate
• CAS No.: 638214-13-8
• Molecular Formula: C₂₆H₂₅F₃O₃
• Molecular Weight: 442.478
• Mol file: 638214-13-8.mol

Synonyms:ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate

Chemical Property of ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate

There total 5 articles about ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester (628333-29-9) + (4'-Trifluoromethyl-biphenyl-3-yl)-methanol (126485-55-0) → ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate (638214-13-8)

Guidance literature:

With diazene-1,2-diylbis(morpholinomethanone); tributylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 22h;

Reference yield:

ethyl (2E)-3-{2-methyl-4-[(phenylmethyl)oxy]phenyl}-2-propenoate (638214-79-6) → ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate (638214-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 19 h / 20 °C

2: diazene-1,2-diylbis(morpholinomethanone); tributylphosphine / tetrahydrofuran / 22 h / 0 - 20 °C

With diazene-1,2-diylbis(morpholinomethanone); tributylphosphine; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; 2: Mitsunobu reaction;

Reference yield:

(3-Bromophenyl)methanol (15852-73-0) → ethyl 3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoate (638214-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / Heating / reflux

2: diazene-1,2-diylbis(morpholinomethanone); tributylphosphine / tetrahydrofuran / 22 h / 0 - 20 °C

With diazene-1,2-diylbis(morpholinomethanone); tributylphosphine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: Suzuki Coupling / 2: Mitsunobu reaction;

upstream raw materials:

3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester

(4'-Trifluoromethyl-biphenyl-3-yl)-methanol

ethyl (2E)-3-{2-methyl-4-[(phenylmethyl)oxy]phenyl}-2-propenoate

(3-Bromophenyl)methanol

Downstream raw materials:

3-[2-methyl-4-({[4'-(trifluoromethyl)-3-biphenylyl]methyl}oxy)phenyl]propanoic acid