4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester

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Chemical Name:4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester
CAS No.:1026471-51-1
Molecular Formula:C₂₈H₃₆N₂O₅
Molecular Weight:480.604
Hs Code.:

Synonyms:4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester

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Chemical Property of 4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester

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Technology Process of 4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester

There total 5 articles about 4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 164033-13-0
(R)-1-phenylbutyl isocyanate

: 142935-42-0
(3R,4S)-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-3-ethyl-3-methylazetidin-2-one

: 1026471-51-1
4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 - 50 ℃; for 19.5h;
DOI:10.1021/jm00013a021

Reference yield:

: 25804-49-3
tert-butyl 4-hydroxybenzoate

: 1026471-51-1
4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / aq. NaOH / acetone / 64 h / Ambient temperature

2: 35 percent / 1,1-dimethylethyl 4-hydroxybenzoate, 2N aq. NaOH / acetone / 24 h / Ambient temperature

3: Et₃N, DMAP / CH₂Cl₂ / 19.5 h / 25 - 50 °C

With dmap; sodium hydroxide; tert-butyl 4-hydroxybenzoate; triethylamine; In dichloromethane; acetone;
DOI:10.1021/jm00013a021

Reference yield:

: (3R,4SR)-4-acetoxy-3-ethyl-3-methylazetidin-2-one

: 1026471-51-1
4-[(2S,3R)-3-Ethyl-3-methyl-4-oxo-1-((R)-1-phenyl-butylcarbamoyl)-azetidin-2-yloxy]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / aq. NaOH / acetone / 64 h / Ambient temperature

2: 35 percent / 1,1-dimethylethyl 4-hydroxybenzoate, 2N aq. NaOH / acetone / 24 h / Ambient temperature

3: Et₃N, DMAP / CH₂Cl₂ / 19.5 h / 25 - 50 °C

With dmap; sodium hydroxide; tert-butyl 4-hydroxybenzoate; triethylamine; In dichloromethane; acetone;
DOI:10.1021/jm00013a021