3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium

Base Information

Chemical Name:3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium
CAS No.:1263050-37-8
Molecular Formula:C₁₈H₁₂F₃N₃O₃
Molecular Weight:375.307
Hs Code.:

Synonyms:3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium

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Chemical Property of 3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium

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Technology Process of 3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium

There total 4 articles about 3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936250-18-9
2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetonitrile

: 1176954-85-0
2-oxido-4-oxo-3-iodo-1-(2,2,2-trifluoroethyl)-4H-pyrido [1,2-a]-pyrimidinium

: 1263050-37-8
3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium

Guidance literature:: With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 372-48-5
2-fluoropyridine

: 1263050-37-8
3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium

Guidance literature:: Multi-step reaction with 4 steps

1: 0.5 h / 220 °C / Microwave irradiation

2: dicyclohexyl-carbodiimide / dichloromethane / 24 h / 20 °C

3: N-iodo-succinimide / N,N-dimethyl-formamide / 0.03 h

4: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.25 h / 150 °C / Microwave irradiation

With N-iodo-succinimide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 77262-41-0
o-<(Trifluoroethyl)amino>pyridine

: 1263050-37-8
3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / dichloromethane / 24 h / 20 °C

2: N-iodo-succinimide / N,N-dimethyl-formamide / 0.03 h

3: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.25 h / 150 °C / Microwave irradiation

With N-iodo-succinimide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;