[1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine

Base Information

• Chemical Name: [1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine
• CAS No.: 125240-62-2
• Molecular Formula: C₁₃H₁₂Cl₂N₆
• Molecular Weight: 323.184
• Mol file: 125240-62-2.mol

Synonyms:[1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine

Chemical Property of [1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine

There total 4 articles about [1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(2,4-dichlorobenzyl)-4-chloro-3-methylpyrazolo<3,4-d>pyrimidine (125240-60-0) → [1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine (125240-62-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Ambient temperature;

DOI:10.1002/jhet.5570260319

Reference yield:

5-amino-4-cyano-1-(2,4-dichlorobenzyl)-3-methylpyrazole (125240-74-6) → [1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine (125240-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / NaOH / ethanol

2: 79 percent

3: 84 percent / POCl₃ / 2 h / Heating

4: 70 percent / 99percent hydrazine hydrate / ethanol / 3 h / Ambient temperature

With sodium hydroxide; hydrazine hydrate; trichlorophosphate; In ethanol;

DOI:10.1002/jhet.5570260319

Reference yield:

5-Amino-1-(2,4-dichloro-benzyl)-3-methyl-1H-pyrazole-4-carboxylic acid amide (125240-96-2) → [1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-hydrazine (125240-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent

2: 84 percent / POCl₃ / 2 h / Heating

3: 70 percent / 99percent hydrazine hydrate / ethanol / 3 h / Ambient temperature

With hydrazine hydrate; trichlorophosphate; In ethanol;

DOI:10.1002/jhet.5570260319

upstream raw materials:

1-(2,4-dichlorobenzyl)-4-chloro-3-methylpyrazolo<3,4-d>pyrimidine

5-amino-4-cyano-1-(2,4-dichlorobenzyl)-3-methylpyrazole

5-Amino-1-(2,4-dichloro-benzyl)-3-methyl-1H-pyrazole-4-carboxylic acid amide

1-(2,4-Dichloro-benzyl)-3-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Downstream raw materials:

7-(2,4-Dichloro-benzyl)-9-methyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine

7-(2,4-Dichloro-benzyl)-2,9-dimethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

7-(2,4-Dichloro-benzyl)-9-methyl-7H-pyrazolo[4,3-e]tetrazolo[1,5-c]pyrimidine

N-[1-(2,4-Dichloro-benzyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-N'-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazine