Technology Process of C21H25NO2
There total 13 articles about C21H25NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1021/jo0703101
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / TBAF / tetrahydrofuran / 2 h / 20 °C
2: 84 percent / NaCNBH3; TFA / CH2Cl2 / 2 h / 0 - 20 °C
3: 84 percent / sodium amalgam / tetrahydrofuran / 22 h / Heating
4: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1 h / 20 °C
With
sodium amalgam; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
4: Swern oxidation;
DOI:10.1021/jo0703101
- Guidance literature:
-
Multi-step reaction with 9 steps
1: NaIO4; NMO; OsO4 / 2-methyl-propan-2-ol; acetone; H2O / 10 h / 20 °C
2: 89 percent / LAH / tetrahydrofuran / 10 h / Heating
3: 79 percent / SOCl2 / CHCl3 / 72 h / 48 °C
4: 79 percent / methanol / 20 h / 20 °C
5: LDA / tetrahydrofuran / 0.07 h / -78 °C
6: 91 percent / TBAF / tetrahydrofuran / 2 h / 20 °C
7: 84 percent / NaCNBH3; TFA / CH2Cl2 / 2 h / 0 - 20 °C
8: 84 percent / sodium amalgam / tetrahydrofuran / 22 h / Heating
9: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1 h / 20 °C
With
sodium periodate; sodium amalgam; osmium(VIII) oxide; lithium aluminium tetrahydride; thionyl chloride; N-methyl-2-indolinone; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetone; tert-butyl alcohol;
9: Swern oxidation;
DOI:10.1021/jo0703101
