1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-(hydroxymethyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-(hydroxymethyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]pyrimidine-2,4(1H,3H)-dione
CAS No.:141684-51-7
Molecular Formula:C₁₇H₂₇N₃O₈SSi
Molecular Weight:461.568
Hs Code.:
Mol file:141684-51-7.mol

1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-(hydroxymethyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]pyrimidine-2,4(1H,3H)-dione

Synonyms:2,4(1H,3H)-Pyrimidinedione,1-[4-amino-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-(hydroxymethyl)-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-,S,S-dioxide, [5S-(5a,6a,8a,9b)]-; 2,4(1H,3H)-Pyrimidinedione, 1-[4-amino-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-(hydroxymethyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-,[5S-(5a,6a,8a,9b)]- (9CI);1,7-Dioxa-2-thiaspiro[4.4]nonane, 2,4(1H,3H)-pyrimidinedione deriv.

Suppliers and Price of 1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-(hydroxymethyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-(hydroxymethyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Density:1.42g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-(hydroxymethyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]pyrimidine-2,4(1H,3H)-dione

There total 3 articles about 1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-(hydroxymethyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 141706-86-7
<1-<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-xylofuranosyl>uracil>-3'-spiro-5''-<4''-amino-1'',2''-oxathiole 2'',2''-dioxide>

: 141684-51-7
<1-<2'-O-(tert-butyldimethylsilyl)-β-D-xylofuranosyl>uracil>-3'-spiro-5''-<4''-amino-1'',2''-oxathiole 2'',2''-dioxide>

Guidance literature:: With hydrogenchloride; for 0.5h; Ambient temperature;
DOI:10.1021/jm00093a002

Reference yield:

: 90813-54-0
2',5'-bis-O-tert-butyldimethylsilyl-3'-ketouridine

: 141684-51-7
<1-<2'-O-(tert-butyldimethylsilyl)-β-D-xylofuranosyl>uracil>-3'-spiro-5''-<4''-amino-1'',2''-oxathiole 2'',2''-dioxide>

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) aq. NaHCO₃, 2.) pyridine / 1.) Et₂O, RT, 16 h, 2.) from 8 deg C to 10 deg C, 48 h

2: 80 percent / Cs₂CO₃ / acetonitrile / 8 h / Ambient temperature

3: 86 percent / 0.1 N methanolic HCl / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydrogencarbonate; caesium carbonate; In acetonitrile;
DOI:10.1021/jm00093a002

Reference yield:

: 141706-84-5
1-<2',5'-bis-O-(tert-butyldimethylsilyl)-3'-C-cyano-3'-O-mesyl-β-D-xylofuranosyl>uracil

: 141684-51-7
<1-<2'-O-(tert-butyldimethylsilyl)-β-D-xylofuranosyl>uracil>-3'-spiro-5''-<4''-amino-1'',2''-oxathiole 2'',2''-dioxide>

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Cs₂CO₃ / acetonitrile / 8 h / Ambient temperature

2: 86 percent / 0.1 N methanolic HCl / 0.5 h / Ambient temperature

With hydrogenchloride; caesium carbonate; In acetonitrile;
DOI:10.1021/jm00093a002