4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide
• CAS No.: 928045-72-1
• Molecular Formula: C₁₇H₂₀F₃NO₂S
• Molecular Weight: 359.413
• Mol file: 928045-72-1.mol

Synonyms:4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide

Chemical Property of 4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide

There total 2 articles about 4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]benzenesulfonamide (928045-67-4) + propargyl bromide (106-96-7) → 4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide (928045-72-1)

Guidance literature:

4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.0833333h; Inert atmosphere;

propargyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/asia.201000139

Reference yield:

N-butylidene-4-methylbenzenesulfonamide (332902-04-2) → 4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide (928045-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sec-butyllithium / diethyl ether; cyclohexane / 0.17 h / -105 °C

1.2: 77 percent / diethyl ether; cyclohexane / 2 h / -105 - -50 °C

2.1: NaH / dimethylformamide / 20 °C

With sec.-butyllithium; sodium hydride; In diethyl ether; cyclohexane; N,N-dimethyl-formamide;

DOI:10.1246/cl.2007.22

Reference yield: 71.0%

4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide (928045-72-1) → 3-propyl-2-(toluene-4-sulfonyl)-3a-trifluoromethyl-2,3,3a,4-tetrahydro-1H-cyclopenta[c]pyrrol-5-one

Guidance literature:

4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]-N-prop-2-yn-1-ylbenzenesulfonamide; dicobalt octacarbonyl; In dichloromethane; at 20 ℃; for 0.5h;

In acetonitrile; at 60 ℃;

DOI:10.1246/cl.2007.22

upstream raw materials:

4-methyl-N-[2-(trifluoromethyl)hex-1-en-3-yl]benzenesulfonamide

propargyl bromide

N-butylidene-4-methylbenzenesulfonamide