C₄₃H₄₁Cl₃N₂O₁₁

Base Information

• Chemical Name: C₄₃H₄₁Cl₃N₂O₁₁
• CAS No.: 945258-82-2
• Molecular Formula: C₄₃H₄₁Cl₃N₂O₁₁
• Molecular Weight: 868.164
• Mol file: 945258-82-2.mol

Synonyms:C₄₃H₄₁Cl₃N₂O₁₁

Chemical Property of C₄₃H₄₁Cl₃N₂O₁₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₄₁Cl₃N₂O₁₁

There total 18 articles about C₄₃H₄₁Cl₃N₂O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C43H41Cl3N2O10 (886437-96-3) → C43H41Cl3N2O11 (945258-82-2)

Guidance literature:

With 2,2-dimethyldioxirane; In dichloromethane; at 0 - 25 ℃; for 1.5h;

DOI:10.1002/anie.200503983

Reference yield:

7-[2-benzyloxy-1-(2,2-dimethoxy-ethylamino)-ethyl]-4-methyl-benzo[1,3]dioxol-5-ol (886438-05-7) → C43H41Cl3N2O11 (945258-82-2)

Guidance literature:

Multi-step reaction with 13 steps

1: 84 percent / NaH / dimethylformamide / 2 h / 0 - 25 °C

2: 90 percent / HCl / dioxane / 72 h / 0 - 25 °C

3: 85 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; triethylamine / CH₂Cl₂ / 24 h / 0 - 25 °C

4: 90 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; buffer solution / CH₂Cl₂ / 0.5 h / 25 °C / pH 7

5: 61 percent / Cu(OTf)2 / benzene / 0.25 h / 85 °C

6: 94 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / 25 °C

7: 93 percent / tributyltin hydride; acetic acid / [(PPh₃)2PdCl₂] / 1 h / 0 - 25 °C

8: CHF₂COOH; MgSO₄ / benzene / 0.75 h / 100 °C

9: 100 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

10: 92 percent / tetrabutylammonium iodide / toluene / 3 h / 110 °C

11: tetrabutylammonium fluoride / CH₂Cl₂ / 0.03 h / 0 °C

12: N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h

13: 2,2-dimethyldioxirane / CH₂Cl₂ / 1.5 h / 0 - 25 °C

With hydrogenchloride; Difluoroacetic acid; 2,2-dimethyldioxirane; buffer solution; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; tetra-(n-butyl)ammonium iodide; copper(II) bis(trifluoromethanesulfonate); sodium hydride; magnesium sulfate; Dess-Martin periodane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1002/anie.200503983

Reference yield:

2-benzyloxy-1-[6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-benzo[1,3]dioxol-4-yl]-ethanone (886437-85-0) → C43H41Cl3N2O11 (945258-82-2)

Guidance literature:

Multi-step reaction with 16 steps

1.1: HCO₂H; triethylamine / Noyori (R,R)-catalyst / dimethylformamide / 24 h / 0 - 40 °C

1.2: diphenylphosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene; dimethylformamide / 24 h / 50 °C

1.3: H₂ / Pd/C / ethyl acetate / 15 h / 25 °C

2.1: acetic acid; NaCNBH₃; MgSO₄ / methanol / 4 h / 0 - 65 °C

3.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

4.1: 84 percent / NaH / dimethylformamide / 2 h / 0 - 25 °C

5.1: 90 percent / HCl / dioxane / 72 h / 0 - 25 °C

6.1: 85 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; triethylamine / CH₂Cl₂ / 24 h / 0 - 25 °C

7.1: 90 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; buffer solution / CH₂Cl₂ / 0.5 h / 25 °C / pH 7

8.1: 61 percent / Cu(OTf)2 / benzene / 0.25 h / 85 °C

9.1: 94 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / 25 °C

10.1: 93 percent / tributyltin hydride; acetic acid / [(PPh₃)2PdCl₂] / 1 h / 0 - 25 °C

11.1: CHF₂COOH; MgSO₄ / benzene / 0.75 h / 100 °C

12.1: 100 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

13.1: 92 percent / tetrabutylammonium iodide / toluene / 3 h / 110 °C

14.1: tetrabutylammonium fluoride / CH₂Cl₂ / 0.03 h / 0 °C

15.1: N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h

16.1: 2,2-dimethyldioxirane / CH₂Cl₂ / 1.5 h / 0 - 25 °C

With hydrogenchloride; Difluoroacetic acid; formic acid; 2,2-dimethyldioxirane; buffer solution; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; tetra-(n-butyl)ammonium iodide; copper(II) bis(trifluoromethanesulfonate); sodium hydride; sodium cyanoborohydride; magnesium sulfate; Dess-Martin periodane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-triphenylphosphine-palladium(II) chloride; ((1R,2R)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)ruthenium chloride(I) (4-cymene); In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1002/anie.200503983

upstream raw materials:

C₄₃H₄₁Cl₃N₂O₁₀

7-bromo-4-methylbenzo[d][1,3]dioxol-5-ol

(7-bromo-4-methyl-benzo[1,3]dioxol-5-yloxy)-tert-butyl-diphenyl-silane

7-[2-benzyloxy-1-(2,2-dimethoxy-ethylamino)-ethyl]-4-methyl-benzo[1,3]dioxol-5-ol

Downstream raw materials:

C₄₃H₄₃Cl₃N₂O₁₁