<4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

Base Information

Chemical Name:<4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide
CAS No.:109064-98-4
Molecular Formula:C₄₆H₆₂F₂N₆O₈
Molecular Weight:865.03
Hs Code.:

<4(R)-<<<N-(tert-butyloxycarbonyl)-L-phenylalanyl>-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

Synonyms:<4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

Suppliers and Price of <4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

There total 2 articles about <4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.1%

: 13122-90-2
Boc-Phe-Phe-OH

: 109064-97-3
<4-amino-2,2-difluoro-3-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

: 109064-98-4
[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]-L-leucyl-L-phenylalaninamide

: 109064-98-4
<4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

Guidance literature:: With diethylphosphoryl cyanide; triethylamine; In N,N-dimethyl-formamide; at 4 ℃;
DOI:10.1021/jm00392a016

Reference yield: 62.1%

: 13122-90-2
Boc-Phe-Phe-OH

: 109064-97-3
<4-amino-2,2-difluoro-3-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

: 109064-98-4
[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]-L-leucyl-L-phenylalaninamide

: 109064-98-4
<4(R)-<<-L-phenylalanyl>amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

Guidance literature:: With diethylphosphoryl cyanide; triethylamine; In N,N-dimethyl-formamide; at 4 ℃;
DOI:10.1021/jm00392a016

Reference yield: 90.1%

: 109064-98-4
[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]-L-leucyl-L-phenylalaninamide

: 108385-34-8
[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3-oxo-6-methylheptanoyl]-L-leucyl-L-phenylalaninamide

Guidance literature:: With dichloro-acetic acid; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; toluene; Ambient temperature;
DOI:10.1021/jm00392a016