(2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine

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Chemical Name:(2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine
CAS No.:141524-78-9
Molecular Formula:C₂₀H₂₆N₄O₂S
Molecular Weight:386.518
Hs Code.:

Synonyms:(2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine

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Chemical Property of (2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine

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Technology Process of (2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine

There total 8 articles about (2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 87900-18-3,117457-09-7
C₉H₁₅LiN₂O₂

: 5-(chloromethyl)-1-methyl-4-(phenylthio)-1H-imidazole hydrochloride

: 141524-78-9
(2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine

: 141610-84-6
(2R-cis)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine

Guidance literature:: In tetrahydrofuran; at -50 ℃; for 18h;

Reference yield:

: 141524-73-4
1-methyl-4-bromo-5-hydroxymethyl-1H-imidazole

: 141524-78-9
(2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / active γ-MnO2 / CHCl3 / 1 h / Heating

2: 73 percent / NaH / dimethylformamide / 3 h / 120 °C

3: 97 percent / NaBH₄ / methanol / 0.5 h / Ambient temperature

4: 97 percent / SOCl₂ / 1.) 0 deg C, 30 min, 2.) RT, 30 min

5: 1.) butyllithium / 1.) hexane, THF, -78 deg C, 15 min, 2.)a) hexane, THF, -78 deg C, 1 h, b) -50 deg C, 18 h

With manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; sodium hydride; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.1784

Reference yield:

: 141524-76-7
1-methyl-4-(phenylthio)-1H-imidazole-5-methanol

: 141524-78-9
(2R-trans)-2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-<<1-methyl-4-(phenylthio)-1H-imidazol-5-yl>methyl>pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / SOCl₂ / 1.) 0 deg C, 30 min, 2.) RT, 30 min

2: 1.) butyllithium / 1.) hexane, THF, -78 deg C, 15 min, 2.)a) hexane, THF, -78 deg C, 1 h, b) -50 deg C, 18 h

With n-butyllithium; thionyl chloride;
DOI:10.1248/cpb.42.1784