[5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester

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Chemical Name:[5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester
CAS No.:211036-93-0
Molecular Formula:C₂₆H₃₈O₇
Molecular Weight:462.584
Hs Code.:

Synonyms:[5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester

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Chemical Property of [5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester

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Technology Process of [5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester

There total 7 articles about [5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: [5-(2-hydroxy-propyl)-tetrahydrofuran-2-yl] acetic acid methyl ester

: [5-(2-benzyloxy-propyl)-tetrahydrofuran-2-yl] acetic acid

: 211036-93-0
[5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester

Guidance literature:: With dmap; 2`,3`-dideoxycytidine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(98)00427-X

Reference yield:

: chloro acetic acid 1-(2benzyloxypropyl)-but-3-enyl ester

: 211036-93-0
[5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 54.35 percent / H₂O; H₂O₂ / BH₃ / tetrahydrofuran; H₂O / 3 h / 20 - 50 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 0 °C

3: 84 percent / toluene / 0.75 h / Heating

4: 96 percent / NaOMe / methanol / 2 h / 20 °C

5: 90 percent / NaI; TMSCl / acetonitrile / 6 h / 0 - 20 °C

6: 83 percent / DDC; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; chloro-trimethyl-silane; water; dihydrogen peroxide; sodium methylate; Dess-Martin periodane; 2`,3`-dideoxycytidine; sodium iodide; borane; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile; 1: Hydrogenolysis / 2: Oxidation / 3: Condensation / 4: Cyclization / 5: debenzylation / 6: Dimerization;
DOI:10.1016/S0040-4020(98)00427-X

Reference yield:

: 91796-51-9
(4RS,6RS)-6-(Phenylmethoxy)hept-1-en-4-ol

: 211036-93-0
[5-(2-benzyloxy-propyl)-tetrahydro-furan-2-yl]-acetic acid 2-(5-methoxycarbonylmethyl-tetrahydro-furan-2-yl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 54.35 percent / H₂O; H₂O₂ / BH₃ / tetrahydrofuran; H₂O / 3 h / 20 - 50 °C

3: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 0 °C

4: 84 percent / toluene / 0.75 h / Heating

5: 96 percent / NaOMe / methanol / 2 h / 20 °C

6: 90 percent / NaI; TMSCl / acetonitrile / 6 h / 0 - 20 °C

7: 83 percent / DDC; DMAP / CH₂Cl₂ / 12 h / 20 °C

With pyridine; dmap; chloro-trimethyl-silane; water; dihydrogen peroxide; sodium methylate; Dess-Martin periodane; 2`,3`-dideoxycytidine; sodium iodide; borane; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile; 1: Acylation / 2: Hydrogenolysis / 3: Oxidation / 4: Condensation / 5: Cyclization / 6: debenzylation / 7: Dimerization;
DOI:10.1016/S0040-4020(98)00427-X