4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt

Base Information

• Chemical Name: 4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt
• CAS No.: 1415797-82-8
• Molecular Formula: C₃₂H₃₁N₂O₅SSi*Na
• Molecular Weight: 606.75
• Mol file: 1415797-82-8.mol

Synonyms:4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt

Chemical Property of 4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt

There total 6 articles about 4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl 5-(2-(2-(tert-butyldiphenylsilyloxo)ethyl)phenyl-2-methoxycarbonylacetamido)thiazole-4-formate (1415797-81-7) → 4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt (1415797-82-8)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃;

Reference yield:

2-tert-butyldiphenylsilyloxyethylphenyl isothiocyanate (1415797-79-3) → 4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt (1415797-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

2: 1,2-dichloro-ethane / 3 h / Reflux; Inert atmosphere

3: sodium methylate / methanol / 20 °C

With potassium tert-butylate; sodium methylate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-7-oxy sodium salt (1415797-82-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: triethylamine / ethyl acetate / 2 h / 0 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

4.1: 1,2-dichloro-ethane / 3 h / Reflux; Inert atmosphere

5.1: sodium methylate / methanol / 20 °C

With potassium tert-butylate; sodium methylate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethyl acetate; 1,2-dichloro-ethane;

upstream raw materials:

2-aminophenethyl alcohol

tert-butylchlorodiphenylsilane

2-tert-butyldiphenylsilyloxyethylaniline

2-tert-butyldiphenylsilyloxyethylphenyl isothiocyanate

Downstream raw materials:

methyl 4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

4-(2-(2-(tert-butyldiphenylsilyloxy)ethyl)phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formic acid

N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-4-(2-(2-hydroxyethyl)phenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

C₄₂H₃₈FN₅O₄SSi

Refernces