N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole

Base Information

Chemical Name:N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole
CAS No.:1391823-36-1
Molecular Formula:C₂₃H₂₀Cl₂N₄O₂S₂
Molecular Weight:519.475
Hs Code.:

Synonyms:N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole

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Chemical Property of N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole

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Technology Process of N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole

There total 4 articles about N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1391823-17-8
N-3-[(2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole

: 587-04-2
m-Chlorobenzaldehyde

: 1391823-36-1
N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole

Guidance literature:: With sodium ethanolate; In methanol; at 80 - 90 ℃;
DOI:10.1007/s12039-011-0123-2

Reference yield:

: 1268705-87-8
N-(3-chloropropyl)-2-aminothiazole

: 1391823-36-1
N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 8 h / 20 °C

2: methanol / 20 °C / Heating

3: zinc(II) chloride / methanol / 80 - 90 °C

4: sodium ethanolate / methanol / 80 - 90 °C

With sodium ethanolate; zinc(II) chloride; In methanol; 4: Knoevenagel condensation;
DOI:10.1007/s12039-011-0123-2

Reference yield:

: 1268705-88-9
N-{3-(aminocarbamyl)-propyl}-2-aminothiazole

: 1391823-36-1
N-3-[{-5-(3-chlorobenzylidene)-2-(3-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 20 °C / Heating

2: zinc(II) chloride / methanol / 80 - 90 °C

3: sodium ethanolate / methanol / 80 - 90 °C

With sodium ethanolate; zinc(II) chloride; In methanol; 3: Knoevenagel condensation;
DOI:10.1007/s12039-011-0123-2