4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(9-carbazolyl)ethyl>-1,2,3,4,4a,9b-hexahydro-γ-carboline

Base Information

• Chemical Name: 4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(9-carbazolyl)ethyl>-1,2,3,4,4a,9b-hexahydro-γ-carboline
• CAS No.: 98634-59-4
• Molecular Formula: C₃₁H₂₇F₂N₃
• Molecular Weight: 479.572
• Mol file: 98634-59-4.mol

Synonyms:4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(9-carbazolyl)ethyl>-1,2,3,4,4a,9b-hexahydro-γ-carboline

Chemical Property of 4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(9-carbazolyl)ethyl>-1,2,3,4,4a,9b-hexahydro-γ-carboline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(9-carbazolyl)ethyl>-1,2,3,4,4a,9b-hexahydro-γ-carboline

There total 1 articles about 4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(9-carbazolyl)ethyl>-1,2,3,4,4a,9b-hexahydro-γ-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

9-(β-chloroethyl)carbazole (1140-35-8) + (+/-)-4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2,3,4,4a,5,9a-hexahydro-1H-pyrido<4,3-b>indole (69623-07-0) → 4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(9-carbazolyl)ethyl>-1,2,3,4,4a,9b-hexahydro-γ-carboline (98634-59-4)

Guidance literature:

With sodium carbonate; potassium iodide; In various solvent(s); 1.) from 80 deg C to 90 deg C, 18 h, 2.) from 120 deg C to 130 deg C, 72 h;

DOI:10.1021/jm00151a002

upstream raw materials:

9-(β-chloroethyl)carbazole

(+/-)-4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2,3,4,4a,5,9a-hexahydro-1H-pyrido<4,3-b>indole