3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone

Base Information

Chemical Name:3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone
CAS No.:1145658-89-4
Molecular Formula:C₂₃H₂₄F₆O₂
Molecular Weight:446.433
Hs Code.:

Synonyms:3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone

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Chemical Property of 3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone

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Technology Process of 3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone

There total 2 articles about 3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: 1438105-96-4
(1H-benzo[d][1,2,3]triazol-1-yl)(3,5-di-tert-butyl-2-hydroxyphenyl)methanone

: 1145658-89-4
3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone

Guidance literature:: 3,6-bis(trifluoromethyl)bromobenzene; With iodine; magnesium; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere; Schlenk technique;

(1H-benzo[d][1,2,3]triazol-1-yl)(3,5-di-tert-butyl-2-hydroxyphenyl)methanone; In tetrahydrofuran; at 23 ℃; for 16h; Inert atmosphere; Schlenk technique;

With water; ammonium chloride; In tetrahydrofuran; Cooling with ice; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.tetasy.2013.03.017

Reference yield:

: 19715-19-6
3,5-ditertbutyl salicylic acid

: 1145658-89-4
3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / 0.75 h / 20 °C / Inert atmosphere; Schlenk technique

1.2: 24 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: magnesium; iodine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 16 h / 23 °C / Inert atmosphere; Schlenk technique

2.3: Cooling with ice; Inert atmosphere; Schlenk technique

With thionyl chloride; iodine; magnesium; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2013.03.017

Reference yield: 50.0%

: 1145658-89-4
3,5-bis(trifluoromethyl)phenyl-(3,5-di-tert-butyl-2-hydroxyphenyl)methanone

: 112245-13-3
(S)-tert-leucinol

: 1145658-86-1
(S,E)-2-(3,5-bis(trifluoromethyl)phenyl-(1-hydroxy-3,3-dimethylbutan-2-ylimino)methyl)-4,6-di-tert-butylphenol

Guidance literature:: With sodium sulfate; In toluene; at 115 ℃; for 48h; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.tetasy.2013.03.017