2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester
CAS No.:296264-52-3
Molecular Formula:C₂₃H₃₃NO₅
Molecular Weight:403.519
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester

There total 7 articles about 2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 2,2-Dimethyl-propionic acid (2R,3R)-2-amino-5-(2,2-dimethyl-propionyloxy)-3-o-tolyl-pentyl ester

: 296264-52-3
2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/S0040-4039(00)00765-6

Reference yield:

: 95-46-5
2-methylphenyl bromide

: 296264-52-3
2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: I₂; Mg / tetrahydrofuran / 12 h / 20 °C

1.2: CuI / tetrahydrofuran / 1 h / -78 - -20 °C

1.3: TMSCl / tetrahydrofuran / 12 h / -78 °C

2.1: LiBH₄ / methanol

3.1: PTSA / methanol

4.1: pyridine

5.1: 97 percent / resorcinol; CF₃COOH / toluene / 6 h / 0 °C

6.1: 93 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

With pyridine; lithium borohydride; iodine; toluene-4-sulfonic acid; magnesium; trifluoroacetic acid; recorcinol; In tetrahydrofuran; pyridine; methanol; dichloromethane; toluene; 1.1: Metallation / 1.2: Metallation / 1.3: Grignard reaction / 2.1: Reduction / 3.1: Substitution / 4.1: Acylation / 5.1: Substitution / 6.1: Condensation;
DOI:10.1016/S0040-4039(00)00765-6

Reference yield:

: 123751-09-7
tert-butyl (4R)-4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 296264-52-3
2,2-Dimethyl-propionic acid (2R,3R)-5-(2,2-dimethyl-propionyloxy)-2-isocyanato-3-o-tolyl-pentyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: I₂; Mg / tetrahydrofuran / 12 h / 20 °C

1.2: CuI / tetrahydrofuran / 1 h / -78 - -20 °C

1.3: TMSCl / tetrahydrofuran / 12 h / -78 °C

2.1: LiBH₄ / methanol

3.1: PTSA / methanol

4.1: pyridine

5.1: 97 percent / resorcinol; CF₃COOH / toluene / 6 h / 0 °C

6.1: 93 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

With pyridine; lithium borohydride; iodine; toluene-4-sulfonic acid; magnesium; trifluoroacetic acid; recorcinol; In tetrahydrofuran; pyridine; methanol; dichloromethane; toluene; 1.1: Metallation / 1.2: Metallation / 1.3: Grignard reaction / 2.1: Reduction / 3.1: Substitution / 4.1: Acylation / 5.1: Substitution / 6.1: Condensation;
DOI:10.1016/S0040-4039(00)00765-6