2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine

Base Information

Chemical Name:2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine
CAS No.:1353968-20-3
Molecular Formula:C₂₇H₁₈FN₅
Molecular Weight:431.472
Hs Code.:

Synonyms:2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine

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Chemical Property of 2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine

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Technology Process of 2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine

There total 3 articles about 2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81045-39-8
5,8-dibromoisoquinoline

: 1323919-50-1
2-(2-fluoro-phenyl)-[1,8]naphthyridine-4-boronic acid

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1353967-97-1
2-(2-fluoro-phenyl)-4-[8-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-5-yl]-[1,8]naphthyridine

: 1353968-20-3
2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine

Guidance literature:: 5,8-dibromoisoquinoline; 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; With potassium phosphate tribasic trihydrate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 80 ℃; for 18h; Inert atmosphere;

2-(2-fluoro-phenyl)-[1,8]naphthyridine-4-boronic acid; With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1323919-50-1
2-(2-fluoro-phenyl)-[1,8]naphthyridine-4-boronic acid

: 1353970-21-4
8-bromo-5-(1-methyl-1H-pyrazol-4-yl)-isoquinoline

: 1353968-20-3
2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 81045-39-8
5,8-dibromoisoquinoline

: 1353968-20-3
2-(2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-8-yl]-[1,8]naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate tribasic trihydrate / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate tribasic trihydrate; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;