allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

Base Information

Chemical Name:allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate
CAS No.:1275616-70-0
Molecular Formula:C₃₅H₅₅N₃O₈SSi
Molecular Weight:705.988
Hs Code.:

allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

Synonyms:allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

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Chemical Property of allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

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Technology Process of allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

There total 2 articles about allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1275616-69-7
3-(2,2-dimethyl-1,3-dioxan-5-yl)propionic acid

: 173152-60-8
allyl 2-{(R)-2-amino-2-[3-methyl-1,2,4-oxadiazol-5-yl]-ethylsulfanylmethyl}-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

: 1275616-70-0
allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

Guidance literature:: With 1,2-dichloro-ethane; In acetonitrile; at 0 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm1014023

Reference yield:

: 141096-58-4
5-<2-(ethoxycarbonyl)ethyl>-2,2-dimethyl-1,3-dioxane

: 1275616-70-0
allyl 2-[(R)-2-[3-(2,2-dimethyl-[1,3]dioxan-5-yl)propionylamino]-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-5-methoxy-6-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / 1 h / 50 °C / Inert atmosphere

2: 1,2-dichloro-ethane / acetonitrile / 5 h / 0 °C / Inert atmosphere

With 1,2-dichloro-ethane; potassium hydroxide; In methanol; acetonitrile;
DOI:10.1021/jm1014023