2-(2-aMino-5-(1-ethyl-1H-indol-5-yl)pyriMidin-4-yl)phenol

Base Information

Chemical Name:2-(2-aMino-5-(1-ethyl-1H-indol-5-yl)pyriMidin-4-yl)phenol
CAS No.:1289141-75-8
Molecular Formula:C₂₀H₁₈N₄O
Molecular Weight:330.389
Hs Code.:
Mol file:1289141-75-8.mol

Synonyms:2-(2-amino-5-(1-ethyl-1H-indol-5-yl) pyrimidin-4-yl) phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-aMino-5-(1-ethyl-1H-indol-5-yl)pyriMidin-4-yl)phenol

Chemical Property:

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Technology Process of 2-(2-aMino-5-(1-ethyl-1H-indol-5-yl)pyriMidin-4-yl)phenol

There total 3 articles about 2-(2-aMino-5-(1-ethyl-1H-indol-5-yl)pyriMidin-4-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1289141-99-6
C₁₉H₁₅NO₂

: 124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9
guanidine hydrogen carbonate

: 1289141-75-8
2-(2-amino-5-(1-ethyl-1H-indol-5-yl) pyrimidin-4-yl) phenol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 6h;
DOI:10.1021/jm101388d

Reference yield:

: 195253-49-7
1-ethyl-5-bromo-1H-indole

: 1289141-75-8
2-(2-amino-5-(1-ethyl-1H-indol-5-yl) pyrimidin-4-yl) phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: -78 - 20 °C

2.1: palladium 10% on activated carbon; potassium carbonate / water; acetonitrile / 4 h / 50 - 60 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 - 90 °C

With n-butyllithium; palladium 10% on activated carbon; potassium carbonate; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetonitrile; 2.1: Suzuki coupling;
DOI:10.1021/jm101388d

Reference yield:

: 952319-69-6
(1-ethyl-1H-indol-5-yl)boronic acid

: 122775-34-2
3-iodo-chromen-4-one

: 1289141-75-8
2-(2-amino-5-(1-ethyl-1H-indol-5-yl) pyrimidin-4-yl) phenol

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; potassium carbonate / water; acetonitrile / 4 h / 50 - 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 - 90 °C

With palladium 10% on activated carbon; potassium carbonate; In water; N,N-dimethyl-formamide; acetonitrile; 1: Suzuki coupling;
DOI:10.1021/jm101388d